/* Reset and Base Styles */
* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

body {
    font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
    line-height: 1.6;
    color: #333;
    background-color: #fff;
}

.container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 0 20px;
}

/* Header and Navigation */
header {
    background: #fff;
    box-shadow: 0 2px 10px rgba(0,0,0,0.1);
    position: fixed;
    width: 100%;
    top: 0;
    z-index: 1000;
}

.nav-container {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 1rem 20px;
    max-width: 1200px;
    margin: 0 auto;
}

.logo h1 {
    color: #2c5282;
    font-size: 1.8rem;
    font-weight: 700;
}

.nav-menu {
    display: flex;
    list-style: none;
    gap: 2rem;
}

.nav-menu a {
    text-decoration: none;
    color: #333;
    font-weight: 500;
    transition: color 0.3s ease;
}

.nav-menu a:hover {
    color: #2c5282;
}

/* Language Switcher */
.language-switcher {
    display: flex;
    gap: 0.5rem;
    align-items: center;
}

.lang-link {
    text-decoration: none;
    color: #666;
    font-weight: 500;
    padding: 0.5rem 1rem;
    border-radius: 6px;
    transition: all 0.3s ease;
    border: 1px solid #e2e8f0;
}

.lang-link:hover {
    background: #f8f9fa;
    color: #2c5282;
}

.lang-link.active {
    background: #2c5282;
    color: #fff;
    border-color: #2c5282;
}

/* Hero Section */
.hero {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    padding: 100px 0 80px;
    text-align: center;
}

.hero h2 {
    font-size: 3rem;
    margin-bottom: 1rem;
    font-weight: 700;
}

.hero-subtitle {
    font-size: 1.25rem;
    margin-bottom: 2rem;
    opacity: 0.9;
    max-width: 800px;
    margin-left: auto;
    margin-right: auto;
}

.patent-notice {
    background: rgba(255, 255, 255, 0.2);
    padding: 1rem;
    border-radius: 8px;
    margin-bottom: 2rem;
    backdrop-filter: blur(10px);
}

.patent-notice p {
    font-size: 1.1rem;
    font-weight: 600;
}

.cta-buttons {
    display: flex;
    gap: 1rem;
    justify-content: center;
    flex-wrap: wrap;
}

.btn {
    padding: 12px 30px;
    border-radius: 6px;
    text-decoration: none;
    font-weight: 600;
    transition: all 0.3s ease;
    display: inline-block;
}

.btn-primary {
    background: #fff;
    color: #2c5282;
}

.btn-primary:hover {
    background: #f7fafc;
    transform: translateY(-2px);
}

.btn-secondary {
    background: transparent;
    color: #fff;
    border: 2px solid #fff;
}

.btn-secondary:hover {
    background: #fff;
    color: #2c5282;
}

/* Sections */
.section {
    padding: 80px 0;
}

.section h2 {
    font-size: 2.5rem;
    margin-bottom: 3rem;
    text-align: center;
    color: #2c5282;
}

.bg-light {
    background: #f8f9fa;
}

/* Problem Section */
.problem-content {
    max-width: 800px;
    margin: 0 auto;
    text-align: center;
}

.problem-text p {
    font-size: 1.1rem;
    margin-bottom: 2rem;
    color: #555;
}

.stats {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 2rem;
    margin: 3rem 0;
}

.stat-item {
    background: #fff;
    padding: 2rem;
    border-radius: 12px;
    box-shadow: 0 4px 20px rgba(0,0,0,0.1);
    text-align: center;
}

.stat-item h3 {
    color: #2c5282;
    font-size: 1.8rem;
    margin-bottom: 0.5rem;
}

.stat-item p {
    color: #666;
    font-weight: 500;
}

.external-links {
    margin-top: 3rem;
    text-align: left;
}

.external-links h3 {
    color: #2c5282;
    margin-bottom: 1rem;
}

.external-links ul {
    list-style: none;
}

.external-links li {
    margin-bottom: 0.5rem;
}

.external-links a {
    color: #2c5282;
    text-decoration: none;
    font-weight: 500;
}

.external-links a:hover {
    text-decoration: underline;
}

/* Solution Section */
.solution-content {
    max-width: 900px;
    margin: 0 auto;
    text-align: center;
}

.solution-content > p {
    font-size: 1.1rem;
    margin-bottom: 3rem;
    color: #555;
}

.solution-features {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 2rem;
    margin: 3rem 0;
}

.feature {
    background: #fff;
    padding: 2rem;
    border-radius: 12px;
    box-shadow: 0 4px 20px rgba(0,0,0,0.1);
    transition: transform 0.3s ease;
}

.feature:hover {
    transform: translateY(-5px);
}

.feature h3 {
    color: #2c5282;
    margin-bottom: 1rem;
    font-size: 1.3rem;
}

.feature p {
    color: #666;
}

.patent-info {
    background: #e6f3ff;
    padding: 1.5rem;
    border-radius: 8px;
    margin-top: 2rem;
    border-left: 4px solid #2c5282;
}

.patent-info p {
    color: #2c5282;
    font-size: 1.1rem;
}

/* Clinical Trial Section */
.trial-content {
    max-width: 800px;
    margin: 0 auto;
    text-align: center;
}

.trial-content > p {
    font-size: 1.1rem;
    margin-bottom: 3rem;
    color: #555;
}

.trial-highlights {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 2rem;
}

.highlight {
    background: #fff;
    padding: 2rem;
    border-radius: 12px;
    box-shadow: 0 4px 20px rgba(0,0,0,0.1);
}

.highlight h3 {
    color: #2c5282;
    margin-bottom: 1rem;
    font-size: 1.3rem;
}

.highlight p {
    color: #666;
}

/* Team Section */
.team-content {
    display: grid;
    grid-template-columns: 1fr 2fr;
    gap: 3rem;
    margin-top: 2rem;
}

.team-leader {
    background: #fff;
    padding: 2rem;
    border-radius: 12px;
    box-shadow: 0 4px 20px rgba(0,0,0,0.1);
    text-align: center;
    align-self: start;
}

.team-leader h3 {
    color: #2c5282;
    margin-bottom: 0.5rem;
    font-size: 1.4rem;
}

.role {
    color: #666;
    font-weight: 600;
    margin-bottom: 1rem;
    font-style: italic;
}

.team-leader p:last-child {
    color: #555;
    font-size: 0.95rem;
}

.team-expertise {
    background: #fff;
    padding: 2rem;
    border-radius: 12px;
    box-shadow: 0 4px 20px rgba(0,0,0,0.1);
}

.team-expertise h3 {
    color: #2c5282;
    margin-bottom: 1rem;
    font-size: 1.4rem;
}

.team-expertise > p {
    color: #555;
    margin-bottom: 2rem;
}

.expertise-areas {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 1.5rem;
}

.expertise-item {
    padding: 1.5rem;
    background: #f8f9fa;
    border-radius: 8px;
    border-left: 4px solid #2c5282;
}

.expertise-item h4 {
    color: #2c5282;
    margin-bottom: 0.5rem;
    font-size: 1.1rem;
}

.expertise-item p {
    color: #666;
    font-size: 0.9rem;
    line-height: 1.5;
}

/* Contact Section */
.contact-content {
    max-width: 600px;
    margin: 0 auto;
    text-align: center;
}

.contact-info h3 {
    color: #2c5282;
    margin-bottom: 1rem;
    font-size: 1.5rem;
}

.contact-info > p {
    color: #666;
    margin-bottom: 2rem;
    font-size: 1.1rem;
}

.contact-details {
    background: #f8f9fa;
    padding: 1.5rem;
    border-radius: 8px;
    margin-bottom: 2rem;
}

.contact-item {
    margin-bottom: 0.5rem;
    font-size: 1.1rem;
}

.contact-item a {
    color: #2c5282;
    text-decoration: none;
    font-weight: 500;
}

.contact-item a:hover {
    text-decoration: underline;
}

.contact-content ul {
    list-style: none;
    text-align: left;
    max-width: 300px;
    margin: 0 auto;
}

.contact-content li {
    margin-bottom: 0.5rem;
    color: #555;
}

.contact-content li:before {
    content: "• ";
    color: #2c5282;
    font-weight: bold;
}

/* Footer */
footer {
    background: #2c5282;
    color: #fff;
    text-align: center;
    padding: 2rem 0;
}

footer p {
    margin-bottom: 0.5rem;
}

/* Responsive Design */
@media (max-width: 768px) {
    .nav-menu {
        display: none;
    }
    
    .nav-container {
        flex-direction: column;
        gap: 1rem;
    }
    
    .language-switcher {
        justify-content: center;
    }
    
    .hero {
        padding: 140px 0 60px;
    }
    
    .hero h2 {
        font-size: 2rem;
    }
    
    .hero-subtitle {
        font-size: 1.1rem;
    }
    
    .section {
        padding: 60px 0;
    }
    
    .section h2 {
        font-size: 2rem;
    }
    
    .cta-buttons {
        flex-direction: column;
        align-items: center;
    }
    
    .btn {
        width: 100%;
        max-width: 300px;
    }
    
    .stats {
        grid-template-columns: 1fr;
    }
    
    .solution-features,
    .trial-highlights {
        grid-template-columns: 1fr;
    }
    
    .team-content {
        grid-template-columns: 1fr;
        gap: 2rem;
    }
    
    .expertise-areas {
        grid-template-columns: 1fr;
    }
}

/* Smooth Scrolling */
html {
    scroll-behavior: smooth;
}

/* Focus States for Accessibility */
a:focus,
.btn:focus {
    outline: 2px solid #2c5282;
    outline-offset: 2px;
}

/* Animation for scroll reveal */
.section {
    animation: fadeInUp 0.6s ease-out;
}

@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}